As part of an industrial cooperation project with a German Car Manufacturer, the authors of this paper applied a matrix-based waste reduction methodology to the case study Multi-Domain Matrix (MDM) model of a sliding sunroof Product Development (PD). The application of the methodology resulted in a reduction of iteration marks by 96.5% in the process model, and the consequences for different waste types are described. In addition, the application of the methodology made possible the identification of meta-teams, which can potentially support better coordination and information flow between the teams involved in the development effort. The study concludes that MDM methodology is potentially a powerful tool for waste elimination in incremental mechatronic product development processes.